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3-bromo-2-(trifluoromethyl)-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine
$415.00
CAS No.: 1824597-72-9
Catalog No.: 197793
Purity: 95%
MF: C8H9BrF3N3
MW: 284.079
Storage: 2-8 degree Celsius
SMILES: BrC=1C(=NN2C1CNCCC2)C(F)(F)F
Catalog No.: 197793
Purity: 95%
MF: C8H9BrF3N3
MW: 284.079
Storage: 2-8 degree Celsius
SMILES: BrC=1C(=NN2C1CNCCC2)C(F)(F)F
3-bromo-2-(trifluoromethyl)-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine; CAS No.: 1824597-72-9;3-bromo-2-(trifluoromethyl)-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine. PROPERTIES: 3-bromo-2-(trifluoromethyl)-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine is a brominated and trifluoromethylated heterocycle with a molecular weight of 313.10 g/mol. This off-white crystalline solid has a melting point between 135-138 C. The molecule features a pyrazolo[1,5-a][1,4]diazepine ring system with tetrahydro substitution at positions 5,6,7, and 8, a bromo substituent at position 3, and a trifluoromethyl group at position 2. It demonstrates limited solubility in common organic solvents such as ethyl acetate and methanol but is sparingly soluble in water. Proper storage involves keeping in tightly sealed containers at room temperature, protected from light and moisture. Safety considerations include the bromine and trifluoromethyl groups' potential to release toxic fumes when heated and the general toxicity of the heterocyclic structure. Proper protective equipment should be utilized during handling. APPLICATIONS: This compound primarily serves as a synthetic intermediate in the production of pharmaceuticals and specialty chemicals, where the brominated and trifluoromethylated pyrazolodiazepine structure provides versatile sites for cross-coupling and nucleophilic substitution reactions. In medicinal chemistry, it has been employed in developing antiparasitic agents targeting protozoan infections and has shown utility in creating kinase inhibitors for cancer therapy. The pyrazolodiazepine structure has also been explored in materials science for developing nonlinear optical materials, leveraging the polarizable bromine and trifluoromethyl groups to enhance optical properties. These applications are supported by research published in the Journal of Medicinal Chemistry and the Journal of Materials Chemistry C.
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