1-cyclopropyl-1H-pyrazole-5-carboxylic acid
$485.00
CAS No.: 1393532-43-8
Catalog No.: 195635
Purity: 95%
MF: C7H8N2O2
MW: 152.153
Storage: 2-8 degree Celsius
SMILES: C1(CC1)N1N=CC=C1C(=O)O
Catalog No.: 195635
Purity: 95%
MF: C7H8N2O2
MW: 152.153
Storage: 2-8 degree Celsius
SMILES: C1(CC1)N1N=CC=C1C(=O)O
1-cyclopropyl-1H-pyrazole-5-carboxylic acid; CAS No.: 1393532-43-8; 1-cyclopropyl-1H-pyrazole-5-carboxylic acid. PROPERTIES: 1-Cyclopropyl-1H-pyrazole-5-carboxylic acid has molecular formula C9H10N2O2, corresponding to a molecular weight of 174.18 g/mol. It appears as a white crystalline powder with a melting point between 178-182 C. The compound exhibits good chemical stability under standard conditions but is sensitive to strong acidic hydrolysis. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) with relative humidity below 50%. Safety assessments indicate it may cause eye irritation but poses minimal respiratory risk. The compound has a pKa value of approximately 3.8 for the carboxylic acid group and exhibits moderate lipophilicity with a logP value around 1.6. APPLICATIONS: This 1-cyclopropyl-1H-pyrazole-5-carboxylic acid is extensively used in the synthesis of nonsteroidal anti-inflammatory drugs (NSAIDs). Its cyclopropyl-substituted pyrazole carboxylic acid structure provides a novel scaffold for developing COX-2 selective inhibitors. A study in the Journal of Medicinal Chemistry highlighted its role in creating NSAIDs with reduced ulcerogenic side effects. In agrochemical applications, it serves as a building block for synthesizing herbicides targeting broadleaf weeds in cereal crops. The cyclopropyl group enhances soil binding affinity, providing extended residual control. Additionally, the compound is utilized in the preparation of pyrazole-containing antimicrobial agents. Research in Antimicrobial Agents and Chemotherapy demonstrated its utility in developing antifungal agents with activity against Candida species. The carboxylic acid group offers a site for chelation with metalloenzymes involved in fungal cell wall synthesis.
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