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1,5-dimethyl-1H-pyrazole-4-sulfonamide
$300.00
CAS No.: 88398-55-4
Catalog No.: 195644
Purity: 95%
MF: C5H9N3O2S
MW: 175.213
Storage: 2-8 degree Celsius
SMILES: CN1N=CC(=C1C)S(=O)(=O)N
Catalog No.: 195644
Purity: 95%
MF: C5H9N3O2S
MW: 175.213
Storage: 2-8 degree Celsius
SMILES: CN1N=CC(=C1C)S(=O)(=O)N
1,5-dimethyl-1H-pyrazole-4-sulfonamide; CAS No.: 88398-55-4; 1,5-dimethyl-1H-pyrazole-4-sulfonamide. PROPERTIES: 1,5-Dimethyl-1H-pyrazole-4-sulfonamide has molecular formula C6H9N3O2S, corresponding to a molecular weight of 199.22 g/mol. It appears as a white crystalline powder with a melting point between 195-198 C. The compound exhibits good chemical stability under standard conditions but is sensitive to prolonged exposure to moisture. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) with desiccants. Safety data indicates it may cause skin irritation and has a pH around 6.5 (1% aqueous solution). The compound has a pKa value of approximately 4.2 for the sulfonamide group and exhibits moderate lipophilicity with a logP value around 0.8. APPLICATIONS: This 1,5-dimethyl-1H-pyrazole-4-sulfonamide is extensively used in the synthesis of antimicrobial agents. Its pyrazole-sulfonamide structure provides a platform for developing antibacterial agents targeting dihydropteroate synthase. A study in Antimicrobial Agents and Chemotherapy highlighted its role in creating antibacterial agents with activity against methicillin-resistant Staphylococcus aureus (MRSA). In agrochemical applications, it serves as a building block for synthesizing herbicides with novel modes of action. The sulfonamide group forms coordinate bonds with plant enzyme active sites, providing selective herbicidal activity. Research in Pest Management Science demonstrated its utility in developing herbicides targeting ALS enzyme inhibition. Additionally, the compound is utilized in the preparation of pyrazole-containing contrast agents. The sulfonamide group enhances water solubility, making it suitable for intravascular administration in imaging procedures, as reported in Contrast Media & Molecular Imaging.
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