2-chloro-3-nitropyrazine
$200.00
CAS No.: 87885-43-6
Catalog No.: 196328
Purity: 95%
MF: C4H2ClN3O2
MW: 159.532
Storage: 2-8 degree Celsius
SMILES: ClC1=NC=CN=C1[N+](=O)[O-]
Catalog No.: 196328
Purity: 95%
MF: C4H2ClN3O2
MW: 159.532
Storage: 2-8 degree Celsius
SMILES: ClC1=NC=CN=C1[N+](=O)[O-]
2-chloro-3-nitropyrazine; CAS No.: 87885-43-6; 2-chloro-3-nitropyrazine. PROPERTIES: This compound features a 2-chloro-3-nitropyrazine structure, combining a chloro substituent and a nitro group on the pyrazine framework. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 163.0 g/mol (C4H2ClN3O2). The melting point ranges between 170-175 C, and it exhibits moderate solubility in common organic solvents like DMSO and DMF while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 2-Chloro-3-nitropyrazine serves as a versatile intermediate in pharmaceutical and chemical synthesis. Its 2-chloro-3-nitropyrazine structure allows for participation in various reactions, including nucleophilic substitution at the chloro position and reduction of the nitro group to amine. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The chloro and nitro groups provide diverse substitution patterns for creating structural analogs. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies employ it as a model compound in Organic Chemistry journals, focusing on the development of novel chloronitropyrazine derivatives based on the 2-chloro-3-nitropyrazine scaffold.
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