1,4'-bipiperidine-1'-carbonyl chloride hydrochloride
$300.00
CAS No.: 143254-82-4
Catalog No.: 196298
Purity: 95%
MF: C11H20Cl2N2O
MW: 267.2
Storage: 2-8 degree Celsius
SMILES: Cl.N1(CCCCC1)C1CCN(CC1)C(=O)Cl
Catalog No.: 196298
Purity: 95%
MF: C11H20Cl2N2O
MW: 267.2
Storage: 2-8 degree Celsius
SMILES: Cl.N1(CCCCC1)C1CCN(CC1)C(=O)Cl
1,4'-bipiperidine-1'-carbonyl chloride hydrochloride; CAS No.: 143254-82-4; 1,4'-bipiperidine-1'-carbonyl chloride hydrochloride. PROPERTIES: This compound features a 1,4'-bipiperidine-1'-carbonyl chloride hydrochloride structure, combining two piperidine rings connected by a carbonyl chloride group and presented as a hydrochloride salt. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 323.3 g/mol (C14H23Cl2N2O). The melting point ranges between 150-155 C, and it exhibits good solubility in common organic solvents like dichloromethane and tetrahydrofuran but is sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE and handling with care due to its reactivity. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 1,4'-Bipiperidine-1'-carbonyl chloride hydrochloride serves as a versatile intermediate in pharmaceutical and chemical synthesis. Its 1,4'-bipiperidine-1'-carbonyl chloride hydrochloride structure enables participation in various reactions, including nucleophilic acylation and coupling reactions to form amides and esters. In medicinal chemistry, it is used to develop bioactive molecules targeting G protein-coupled receptors and ion channels. The carbonyl chloride group provides high reactivity for forming peptide bonds. This compound also functions as a building block in the synthesis of bioactive peptides and depsipeptides. Academic studies employ it as a model compound in Medicinal Chemistry journals, focusing on optimizing the 1,4'-bipiperidine-1'-carbonyl chloride hydrochloride scaffold for improved biological activity and target engagement.
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