tert-butyl 3-oxo-2-phenylpiperazine-1-carboxylate
$250.00
CAS No.: 911705-40-3
Catalog No.: 192811
Purity: 95%
MF: C15H20N2O3
MW: 276.336
Storage: 2-8 degree Celsius
SMILES: O=C1C(N(CCN1)C(=O)OC(C)(C)C)C1=CC=CC=C1
Catalog No.: 192811
Purity: 95%
MF: C15H20N2O3
MW: 276.336
Storage: 2-8 degree Celsius
SMILES: O=C1C(N(CCN1)C(=O)OC(C)(C)C)C1=CC=CC=C1
tert-butyl 3-oxo-2-phenylpiperazine-1-carboxylate; CAS No.: 911705-40-3; tert-butyl 3-oxo-2-phenylpiperazine-1-carboxylate. PROPERTIES: This oxo- and phenyl-substituted piperazine carbamate has molecular formula C19H21N2O3. It appears as a white crystalline powder. The tert-butyl 3-oxo-2-phenylpiperazine-1-carboxylate demonstrates limited water solubility but good solubility in common organic solvents like methanol and ethyl acetate. Its melting point ranges between 120-125 C, and it has a molecular weight of approximately 335.4 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong acids and may undergo carbamate hydrolysis upon exposure to aqueous conditions. In case of spillage, absorb with inert material and dispose of in accordance with local regulations. APPLICATIONS: The tert-butyl 3-oxo-2-phenylpiperazine-1-carboxylate serves as a valuable intermediate in the synthesis of kinase inhibitors for cancer therapy where the piperazinone ring provides essential hydrogen bonding interactions with kinase residues (as detailed in medicinal chemistry literature). The phenyl group enhances metabolic stability by preventing oxidative degradation. Additionally, the compound functions as a building block in the preparation of chiral ligands for asymmetric catalysis, achieving enantiomeric excesses above 95% in certain hydrogenation reactions as described in synthetic chemistry journals. The carbamate group can be further functionalized through hydrolysis or alkylation reactions to produce various derivatives for chemical research applications.
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