(2R,6R)-2,6-dimethylpiperazine dihydrochloride
$300.00
CAS No.: 162240-93-9
Catalog No.: 196268
Purity: 95%
MF: C6H16Cl2N2
MW: 187.114
Storage: 2-8 degree Celsius
SMILES: Cl.Cl.C[C@H]1N[C@@H](CNC1)C
Catalog No.: 196268
Purity: 95%
MF: C6H16Cl2N2
MW: 187.114
Storage: 2-8 degree Celsius
SMILES: Cl.Cl.C[C@H]1N[C@@H](CNC1)C
(2R,6R)-2,6-dimethylpiperazine dihydrochloride; CAS No.: 162240-93-9; (2R,6R)-2,6-dimethylpiperazine dihydrochloride. PROPERTIES: This compound features a (2R,6R)-2,6-dimethylpiperazine dihydrochloride structure, combining two methyl substituents on a piperazine ring and presented as a dihydrochloride salt. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 178.3 g/mol (C6H16N2 {2HCl). The melting point ranges between 200-205 C, and it exhibits good solubility in water and common organic solvents like ethanol and methanol. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: (2R,6R)-2,6-Dimethylpiperazine dihydrochloride serves as a valuable intermediate in pharmaceutical and chemical synthesis. Its (2R,6R)-2,6-dimethylpiperazine dihydrochloride structure enables participation in various reactions, including amide bond formation, nucleophilic substitution at the piperazine nitrogen, and chiral resolution. In medicinal chemistry, it is used to develop bioactive molecules targeting G protein-coupled receptors and ion channels. The dimethyl substituents provide steric protection and metabolic stability. This compound also functions as a building block in the synthesis of bioactive peptides and depsipeptides. Academic studies employ it as a model compound in Medicinal Chemistry journals, focusing on optimizing the (2R,6R)-2,6-dimethylpiperazine dihydrochloride scaffold for improved biological activity and target engagement.
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