piperazin-1-yl(p-tolyl)methanone
$300.00
CAS No.: 111752-26-2
Catalog No.: GS3253
Purity: 95%
MF: C12H16N2O
MW: 204.273
Storage: 2-8 degree Celsius
SMILES: N1(CCNCC1)C(=O)C1=CC=C(C=C1)C
Catalog No.: GS3253
Purity: 95%
MF: C12H16N2O
MW: 204.273
Storage: 2-8 degree Celsius
SMILES: N1(CCNCC1)C(=O)C1=CC=C(C=C1)C
CAS NO.: 111752-26-2;piperazin-1-yl(p-tolyl)methanone. PROPERTIES: This piperazine derivative presents as a white crystalline solid with a molecular weight of approximately 221.3 g/mol. The piperazin-1-yl(p-tolyl)methanone combines a piperazine ring with a p-tolyl group and a ketone functionality. It exhibits moderate solubility in water and good dissolution in lower alcohols and ketones. Stability characterization reveals vulnerability to oxidation and base-catalyzed hydrolysis of the ketone group, necessitating storage at 2-8 degree Celsius in sealed glass containers. Handlers should use powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause localized edema requiring corticosteroid application. Inhalation may induce respiratory alkalosis; treatment includes humidified oxygen administration. Eye exposure requires chelation inhibitors and ophthalmology evaluation. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The piperazin-1-yl(p-tolyl)methanone serves as a key intermediate in the synthesis of various pharmaceuticals. Its piperazine ring provides opportunities for alkylation and acylation reactions. Research teams utilize this compound as a starting material for creating serotonin receptor modulators and antipsychotic agents. The ketone group undergoes reduction to form secondary alcohols for further functionalization. Additionally, it serves as a building block for creating GABA receptor modulators with enhanced subtype selectivity. The compound's unique substitution pattern makes it valuable in the development of kinase inhibitors and ion channel modulators.
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