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[(2S)-oxetan-2-yl]methanol; CAS No.: 2090778-00-8;[(2S)-oxetan-2-yl]methanol. PROPERTIES: [(2S)-oxetan-2-yl]methanol is a chiral oxetane derivative with a molecular weight of 104.12 g/mol. This colorless liquid has a boiling point around 105-107 C at 760 mmHg. The molecule features an oxetane ring with a hydroxymethyl group at position 2 in the (2S) configuration. It demonstrates moderate solubility in common organic solvents such as ethanol and acetone and limited water solubility. Proper storage involves keeping in tightly sealed containers at room temperature, protected from light and moisture. Safety considerations include the alcohol group's flammability and the oxetane ring's potential to cause skin irritation. Standard laboratory safety protocols should be observed. APPLICATIONS: This compound primarily functions as a chiral building block in the synthesis of pharmaceuticals and specialty chemicals, where the oxetane ring provides structural diversity for receptor interactions. In medicinal chemistry, it has been employed in developing antiviral agents targeting RNA viruses and has shown utility in creating kinase inhibitors for cancer therapy. The chiral oxetane structure has also been explored in materials science for developing chiral ligands in asymmetric catalysis, leveraging the stereogenic center's effects on reaction selectivity. These applications are supported by research published in the Journal of Medicinal Chemistry and the Journal of Catalysis.