tert-butyl 4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate
$200.00
CAS No.: 280110-69-2
Catalog No.: 196310
Purity: 95%
MF: C13H21N3O3
MW: 267.329
Storage: 2-8 degree Celsius
SMILES: CC1=NN=C(O1)C1CCN(CC1)C(=O)OC(C)(C)C
Catalog No.: 196310
Purity: 95%
MF: C13H21N3O3
MW: 267.329
Storage: 2-8 degree Celsius
SMILES: CC1=NN=C(O1)C1CCN(CC1)C(=O)OC(C)(C)C
tert-butyl 4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate; CAS No.: 280110-69-2; tert-butyl 4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate. PROPERTIES: This compound features a tert-butyl 4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate structure, combining a tert-butyl ester, a methyl-substituted oxadiazole group, and a piperidine ring system. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 293.3 g/mol (C14H20N4O2). The melting point ranges between 120-125 C, and it exhibits moderate solubility in common organic solvents like ethyl acetate, dichloromethane, and tetrahydrofuran while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: tert-Butyl 4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate serves as a versatile intermediate in pharmaceutical and chemical synthesis. Its tert-butyl 4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate structure allows for participation in various reactions, including ester hydrolysis, nucleophilic substitution at the oxadiazole ring, and hydrogen bonding interactions through the piperidine nitrogen. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The tert-butyl ester provides temporary protection for the carboxylic acid, allowing sequential synthesis steps. This compound also functions as a building block in the synthesis of bioactive peptides and depsipeptides. Academic studies employ it as a model compound in Medicinal Chemistry journals, focusing on optimizing the tert-butyl 4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate scaffold for improved biological activity and pharmacokinetic properties.
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