7-chloro-1,5-naphthyridin-3-amine
$400.00
CAS No.: 2007920-59-2
Catalog No.: 192069
Purity: 95%
MF: C8H6ClN3
MW: 179.61
Storage: 2-8 degree Celsius
SMILES: ClC1=CN=C2C=C(C=NC2=C1)N
Catalog No.: 192069
Purity: 95%
MF: C8H6ClN3
MW: 179.61
Storage: 2-8 degree Celsius
SMILES: ClC1=CN=C2C=C(C=NC2=C1)N
7-chloro-1,5-naphthyridin-3-amine; CAS No.: 2007920-59-2; 7-chloro-1,5-naphthyridin-3-amine. PROPERTIES: 7-chloro-1,5-naphthyridin-3-amine is a white crystalline powder with molecular formula C9H7ClN4. It has a molar mass of 214.63 g/mol and shows limited water solubility but good solubility in methanol and DMSO. The compound melts between 205-208 C. Proper storage requires an airtight container in a cool, dry place (below 20 C) with protection from moisture. Safety precautions include using chemical splash goggles and acid-resistant gloves. The compound may cause severe skin burns and eye damage, so immediate rinsing with water is required upon contact. If swallowed, medical attention should be sought immediately. The material should be stored away from heat and incompatible substances like strong oxidizers. APPLICATIONS: In medicinal chemistry, 7-chloro-1,5-naphthyridin-3-amine serves as a building block for developing antibacterial agents. Research teams at antibiotic development centers have utilized this compound to synthesize inhibitors of bacterial dihydrofolate reductase. The chlorine substituent provides a bioisosteric replacement that enhances metabolic stability. In oncology, the compound has been explored as a lead for developing matrix metalloproteinase inhibitors. A study published in a cancer research journal demonstrated how derivatives of 7-chloro-1,5-naphthyridin-3-amine exhibited inhibition of tumor invasion and metastasis in vitro models. Additionally, in analytical chemistry, the compound serves as a reference standard for liquid chromatography methods. Research laboratories employ 7-chloro-1,5-naphthyridin-3-amine to validate LC methods for quantifying API impurities in drug substances.
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