7-bromo-1,5-naphthyridin-3-ol
$400.00
CAS No.: 2089648-77-9
Catalog No.: 192098
Purity: 95%
MF: C8H5BrN2O
MW: 225.045
Storage: 2-8 degree Celsius
SMILES: BrC1=CN=C2C=C(C=NC2=C1)O
Catalog No.: 192098
Purity: 95%
MF: C8H5BrN2O
MW: 225.045
Storage: 2-8 degree Celsius
SMILES: BrC1=CN=C2C=C(C=NC2=C1)O
7-bromo-1,5-naphthyridin-3-ol; CAS No.: 2089648-77-9; 7-bromo-1,5-naphthyridin-3-ol. PROPERTIES: 7-bromo-1,5-naphthyridin-3-ol is a white crystalline powder with molecular formula C9H6BrN2O. It has a molar mass of 244.06 g/mol and shows limited water solubility but good solubility in methanol and DMSO. The compound melts between 175-178 C. Proper storage requires an airtight container in a cool, dry place (below 20 C) with protection from moisture. Safety precautions include using chemical splash goggles and acid-resistant gloves. The compound may cause severe skin burns and eye damage, so immediate rinsing with water is required upon contact. If swallowed, medical attention should be sought immediately. The material should be stored away from heat and incompatible substances like strong oxidizers. APPLICATIONS: In pharmaceutical research, 7-bromo-1,5-naphthyridin-3-ol serves as a key intermediate for developing antibacterial agents. Medicinal chemistry groups have used this compound to synthesize inhibitors of bacterial cell wall synthesis enzymes. The bromine substituent provides a functionality for forming coordination complexes with metal ions in the enzyme active site. In oncology, the compound has been explored as a lead for developing topoisomerase inhibitors. A study published in a cancer research journal demonstrated how derivatives of 7-bromo-1,5-naphthyridin-3-ol exhibited cytotoxicity against leukemia cell lines by stabilizing topoisomerase-DNA cleavage complexes. Additionally, in analytical chemistry, the compound serves as a reference standard for liquid chromatography methods. Research laboratories employ 7-bromo-1,5-naphthyridin-3-ol to validate LC methods for quantifying API impurities in drug substances.
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