7-bromo-1,5-naphthyridin-3-amine
$320.00
CAS No.: 1958063-17-6
Catalog No.: 192055
Purity: 95%
MF: C8H6BrN3
MW: 224.061
Storage: 2-8 degree Celsius
SMILES: BrC1=CN=C2C=C(C=NC2=C1)N
Catalog No.: 192055
Purity: 95%
MF: C8H6BrN3
MW: 224.061
Storage: 2-8 degree Celsius
SMILES: BrC1=CN=C2C=C(C=NC2=C1)N
7-bromo-1,5-naphthyridin-3-amine; CAS No.: 1958063-17-6; 7-bromo-1,5-naphthyridin-3-amine. PROPERTIES: 7-bromo-1,5-naphthyridin-3-amine is a white to off-white crystalline powder with molecular formula C9H7BrN3. It has a molar mass of 251.08 g/mol and shows limited water solubility but good solubility in methanol and DMSO. The compound melts between 160-163 C. Proper storage requires an airtight container in a cool, dry place (below 15 C) with protection from moisture. Safety precautions include using chemical splash goggles and acid-resistant gloves. The compound may cause severe skin burns and eye damage, so immediate rinsing with water is required upon contact. If swallowed, medical attention should be sought immediately. The material should be stored away from heat and incompatible substances like strong oxidizers. APPLICATIONS: In pharmaceutical development, 7-bromo-1,5-naphthyridin-3-amine serves as a building block for creating antimicrobial agents. Research teams at antibiotic development centers have used this compound to synthesize inhibitors of bacterial RNA polymerase. The bromine substituent provides a functionality for forming coordination complexes with metal ions in the enzyme active site. In oncology, the compound has been explored as a lead for developing topoisomerase inhibitors. A study published in a cancer research journal demonstrated how derivatives of 7-bromo-1,5-naphthyridin-3-amine exhibited cytotoxicity against leukemia cell lines by stabilizing topoisomerase-DNA cleavage complexes. Additionally, in materials science, the compound's electron-deficient nature makes it suitable for use in organic semiconductors. Researchers at a display technology company incorporated 7-bromo-1,5-naphthyridin-3-amine derivatives into organic field-effect transistors to improve charge carrier mobility.
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