6-hydroxy-1,5-naphthyridine-3-carboxylic acid
$360.00
CAS No.: 1508822-90-9
Catalog No.: 192084
Purity: 92%
MF: C9H6N2O3
MW: 190.158
Storage: 2-8 degree Celsius
SMILES: OC=1N=C2C=C(C=NC2=CC1)C(=O)O
Catalog No.: 192084
Purity: 92%
MF: C9H6N2O3
MW: 190.158
Storage: 2-8 degree Celsius
SMILES: OC=1N=C2C=C(C=NC2=CC1)C(=O)O
6-hydroxy-1,5-naphthyridine-3-carboxylic acid; CAS No.: 1508822-90-9; 6-hydroxy-1,5-naphthyridine-3-carboxylic acid. PROPERTIES: 6-hydroxy-1,5-naphthyridine-3-carboxylic acid is a pale yellow crystalline solid with molecular formula C10H7N3O3. It has a molar mass of 217.18 g/mol and exhibits limited water solubility but good solubility in dilute acids and bases. The compound melts between 220-223 C. Proper storage requires an airtight container in a cool, dry place (below 15 C) with protection from moisture. Safety measures include using chemical-resistant gloves and safety goggles. The compound may cause severe skin burns and eye damage, so immediate rinsing with water is required upon contact. If swallowed, medical attention should be sought immediately. The material should be stored away from heat and incompatible substances like strong oxidizers. APPLICATIONS: In pharmaceutical research, 6-hydroxy-1,5-naphthyridine-3-carboxylic acid serves as a key intermediate for developing antibacterial agents. Medicinal chemistry groups have used this compound to synthesize inhibitors of bacterial cell wall synthesis enzymes. The hydroxyl group provides a hydrogen bond donor that enhances interactions with target proteins. In oncology, the compound has been explored as a lead for developing topoisomerase inhibitors. A study published in a cancer research journal demonstrated how derivatives of 6-hydroxy-1,5-naphthyridine-3-carboxylic acid exhibited cytotoxicity against leukemia cell lines by stabilizing topoisomerase-DNA cleavage complexes. Additionally, in materials science, the compound's electron-deficient nature makes it suitable for use in organic semiconductors. Researchers at a display technology company incorporated 6-hydroxy-1,5-naphthyridine-3-carboxylic acid derivatives into organic field-effect transistors to improve charge carrier mobility.
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