(R)-5-(hydroxymethyl)-4-methylmorpholin-3-one
$540.00
CAS No.: 960402-19-1
Catalog No.: 192754
Purity: 95%
MF: C6H11NO3
MW: 145.158
Storage: 2-8 degree Celsius
SMILES: OC[C@@H]1COCC(N1C)=O
Catalog No.: 192754
Purity: 95%
MF: C6H11NO3
MW: 145.158
Storage: 2-8 degree Celsius
SMILES: OC[C@@H]1COCC(N1C)=O
(R)-5-(hydroxymethyl)-4-methylmorpholin-3-one; CAS No.: 960402-19-1; (R)-5-(hydroxymethyl)-4-methylmorpholin-3-one. PROPERTIES: This hydroxymethyl-substituted morpholinone has molecular formula C7H14N2O2. It typically appears as a white crystalline powder. The (R)-5-(hydroxymethyl)-4-methylmorpholin-3-one demonstrates limited water solubility but good solubility in common organic solvents like methanol and ethyl acetate. Its melting point ranges between 85-90 C, and it has a molecular weight of approximately 158.19 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong acids and may undergo hydrolysis upon exposure to aqueous conditions. In case of spillage, absorb with inert material and dispose of in accordance with local regulations. APPLICATIONS: The (R)-5-(hydroxymethyl)-4-methylmorpholin-3-one functions as a key intermediate in the synthesis of kinase inhibitors for cancer therapy where the morpholinone ring provides essential hydrogen bonding interactions with kinase residues (as reported in medicinal chemistry literature). The hydroxymethyl group forms additional hydrogen bonds with catalytic residues. Additionally, the compound serves as a building block in the preparation of chiral ligands for asymmetric catalysis, achieving enantiomeric excesses above 95% in certain hydrogenation reactions as described in synthetic chemistry journals. The hydroxyl group can be further functionalized through etherification or esterification reactions to produce various derivatives for chemical research applications.
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