(4-bromo-2-methylphenyl)(morpholino)methanone
$350.00
CAS No.: 276677-17-9
Catalog No.: 196890
Purity: 95%
MF: C12H14BrNO2
MW: 284.153
Storage: 2-8 degree Celsius
SMILES: BrC1=CC(=C(C=C1)C(=O)N1CCOCC1)C
Catalog No.: 196890
Purity: 95%
MF: C12H14BrNO2
MW: 284.153
Storage: 2-8 degree Celsius
SMILES: BrC1=CC(=C(C=C1)C(=O)N1CCOCC1)C
(4-bromo-2-methylphenyl)(morpholino)methanone; CAS No.: 276677-17-9; (4-bromo-2-methylphenyl)(morpholino)methanone. PROPERTIES: This bromo-methyl-substituted phenyl morpholino ketone features molecular formula C??H??BrNO? with molecular weight 283.14 g/mol. It typically exists as a white crystalline powder. Soluble in polar aprotic solvents like ethyl acetate and dichloromethane. Melting point approximately 110-115 C. Exhibits IR absorption for ketone (~1700 cm??) and C-Br groups (~600-500 cm??). Thermogravimetric analysis indicates decomposition above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause mild skin irritation and serious eye damage; therefore, standard laboratory safety precautions including protective clothing and eye protection are recommended during handling. APPLICATIONS: As a bromo-methyl-substituted phenyl morpholino ketone, (4-bromo-2-methylphenyl)(morpholino)methanone is predominantly utilized in the synthesis of kinase inhibitors. It serves as a key intermediate in constructing the core scaffold of these compounds, where the morpholino group provides valuable binding affinity for the kinase active site as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its ketone functionality enables conjugation to biomolecules via oxime formation (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the bromo and methyl substituents contribute to improved flame retardancy and mechanical properties (Polymer International).
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