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5-bromoisoxazolo[5,4-b]pyridine
$850.00
CAS No.: 1246552-55-5
Catalog No.: LT0111
Purity: 95%
MF: C6H3BrN2O
MW: 199.007
Storage: 2-8 degree Celsius
SMILES: BrC=1C=C2C(=NC1)ON=C2
Catalog No.: LT0111
Purity: 95%
MF: C6H3BrN2O
MW: 199.007
Storage: 2-8 degree Celsius
SMILES: BrC=1C=C2C(=NC1)ON=C2
CAS NO.: 1246552-55-5;5-bromoisoxazolo[5,4-b]pyridine. PROPERTIES: This brominated heterocycle presents as a white crystalline solid with a molecular weight of approximately 211.0 g/mol. The 5-bromoisoxazolo[5,4-b]pyridine combines a bromine substituent with a fused isoxazole-pyridine ring system. It exhibits limited aqueous solubility but good dissolution in polar aprotic solvents like DMSO and DMF. Stability characterization reveals sensitivity to nucleophilic aromatic substitution and base-catalyzed ring-opening, necessitating storage at 2-8 degree Celsius in sealed glass containers. Handlers should use powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause mild irritation requiring thorough washing. Inhalation may induce respiratory tract irritation; treatment includes fresh air and medical evaluation. Eye exposure requires extended rinsing and possible corticosteroid application. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The 5-bromoisoxazolo[5,4-b]pyridine functions as a key intermediate in the synthesis of various pharmaceuticals. Its isoxazole-pyridine framework provides opportunities for directed metalation and cross-coupling reactions. Research teams utilize this compound as a starting material for creating kinase inhibitors and ion channel modulators. The bromine substituent offers opportunities for further diversification in medicinal chemistry. Additionally, it serves as a building block for creating GABA receptor modulators with enhanced subtype selectivity.
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