methyl 4-bromoisoquinoline-7-carboxylate
$400.00
CAS No.: 2007916-56-3
Catalog No.: 192063
Purity: 95%
MF: C11H8BrNO2
MW: 266.094
Storage: 2-8 degree Celsius
SMILES: BrC1=CN=CC2=CC(=CC=C12)C(=O)OC
Catalog No.: 192063
Purity: 95%
MF: C11H8BrNO2
MW: 266.094
Storage: 2-8 degree Celsius
SMILES: BrC1=CN=CC2=CC(=CC=C12)C(=O)OC
methyl 4-bromoisoquinoline-7-carboxylate; CAS No.: 2007916-56-3; methyl 4-bromoisoquinoline-7-carboxylate. PROPERTIES: Methyl 4-bromoisoquinoline-7-carboxylate is a white to off-white crystalline powder with molecular formula C11H8BrNO3. It has a molar mass of 273.09 g/mol and shows limited water solubility but good solubility in methanol and ethyl acetate. The compound melts between 185-188 C. Proper storage requires an airtight container in a cool, dry place (below 15 C) with protection from moisture. Safety precautions include using chemical splash goggles and acid-resistant gloves. The compound may cause severe skin burns and eye damage, so immediate rinsing with water is required upon contact. If swallowed, medical attention should be sought immediately. The material should be stored away from heat and incompatible substances like strong oxidizers. APPLICATIONS: In pharmaceutical development, methyl 4-bromoisoquinoline-7-carboxylate serves as a building block for creating antibacterial agents. Research teams at antibiotic development centers have utilized this compound to synthesize inhibitors of bacterial dihydrofolate reductase. The bromine substituent provides a bioisosteric replacement that enhances metabolic stability. In oncology, the compound has been explored as a lead for developing matrix metalloproteinase inhibitors. A study published in a cancer research journal demonstrated how derivatives of methyl 4-bromoisoquinoline-7-carboxylate exhibited inhibition of tumor invasion and metastasis in vitro models. Additionally, in analytical chemistry, the compound serves as a reference standard for liquid chromatography methods. Research laboratories employ methyl 4-bromoisoquinoline-7-carboxylate to validate LC methods for quantifying API impurities in drug substances.
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