5-chloro-6-methoxyisoquinoline
$400.00
CAS No.: 366445-71-8
Catalog No.: 192355
Purity: 95%
MF: C10H8ClNO
MW: 193.633
Storage: 2-8 degree Celsius
SMILES: ClC1=C2C=CN=CC2=CC=C1OC
Catalog No.: 192355
Purity: 95%
MF: C10H8ClNO
MW: 193.633
Storage: 2-8 degree Celsius
SMILES: ClC1=C2C=CN=CC2=CC=C1OC
5-chloro-6-methoxyisoquinoline; CAS No.: 366445-71-8; 5-chloro-6-methoxyisoquinoline. PROPERTIES: 5-chloro-6-methoxyisoquinoline is a crystalline powder with molecular formula C10H7ClNO. It has a melting point of approximately 135-140 C and exhibits moderate solubility in ethanol and methanol. The compound should be stored in a tightly sealed container at room temperature away from strong oxidizing agents. Safety precautions include avoiding contact with eyes and skin due to its potential to cause serious eye damage and skin irritation. APPLICATIONS: This chlorinated, methoxy-substituted isoquinoline is employed in the development of dual kinase/HDAC inhibitors. The amine group facilitates binding to the catalytic site of kinases while the chlorine substituent enhances HDAC inhibitory activity as described in cancer research literature. In chemical biology, 5-chloro-6-methoxyisoquinoline serves as a tag for bioorthogonal labeling. According to biochemical journals, the isoquinoline scaffold provides a fluorescent signal while the amine group enables conjugation with azide-containing biomolecules via click chemistry.
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