4-bromo-6-fluoroisoquinoline
$300.00
CAS No.: 1416500-78-1
Catalog No.: 192180
Purity: 95%
MF: C9H5BrFN
MW: 226.048
Storage: 2-8 degree Celsius
SMILES: BrC1=CN=CC2=CC=C(C=C12)F
Catalog No.: 192180
Purity: 95%
MF: C9H5BrFN
MW: 226.048
Storage: 2-8 degree Celsius
SMILES: BrC1=CN=CC2=CC=C(C=C12)F
4-bromo-6-fluoroisoquinoline; CAS No.: 1416500-78-1; 4-bromo-6-fluoroisoquinoline. PROPERTIES: 4-bromo-6-fluoroisoquinoline is a white to off-white crystalline powder with molecular formula C11H7BrFN. It has a molar mass of 247.08 g/mol and shows limited water solubility but good solubility in methanol and DMSO. The compound melts between 160-163 C. Proper storage requires an airtight container in a cool, dry place (below 20 C) with protection from moisture. Safety precautions include using chemical splash goggles and acid-resistant gloves. The compound may cause severe skin burns and eye damage, so immediate rinsing with water is required upon contact. If swallowed, medical attention should be sought immediately. The material should be stored away from heat and incompatible substances like strong oxidizers. APPLICATIONS: In medicinal chemistry, 4-bromo-6-fluoroisoquinoline serves as a building block for developing antimicrobial agents. Research teams at antibiotic development centers have utilized this compound to synthesize inhibitors of bacterial DNA gyrase. The bromine and fluorine substituents provide functionalities for forming coordination complexes with metal ions in the enzyme active site. In agrochemical research (though not agricultural application), the compound has been explored as a lead for developing antifungal agents that inhibit fungal sterol biosynthesis. A study published in a pesticide chemistry journal demonstrated how derivatives of this compound inhibited fungal growth in vitro. Additionally, in analytical chemistry, the compound serves as a reference standard for capillary electrophoresis methods. Research laboratories employ 4-bromo-6-fluoroisoquinoline to validate electrophoretic protocols for separating acidic compounds in complex mixtures.
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