1-chloro-7-fluoroisoquinoline
$600.00
CAS No.: 630422-89-8
Catalog No.: 191989
Purity: 95%
MF: C9H5ClFN
MW: 181.597
Storage: 2-8 degree Celsius
SMILES: ClC1=NC=CC2=CC=C(C=C12)F
Catalog No.: 191989
Purity: 95%
MF: C9H5ClFN
MW: 181.597
Storage: 2-8 degree Celsius
SMILES: ClC1=NC=CC2=CC=C(C=C12)F
1-chloro-7-fluoroisoquinoline; CAS No.: 630422-89-8; 1-chloro-7-fluoroisoquinoline. PROPERTIES: 1-chloro-7-fluoroisoquinoline is a halogenated heterocyclic compound characterized by a pale yellow crystalline solid with a molecular weight of 185.59 g/mol. It exhibits moderate solubility in polar organic solvents like dichloromethane or ethyl acetate but low solubility in water. The compound is sensitive to moisture and light, requiring storage in airtight containers under inert gas (e.g., nitrogen) at 2 C8 C to prevent decomposition. Thermal stability is limited, with decomposition observed above 150 C. Safety precautions include wearing gloves and eye protection due to potential skin/eye irritation, and adequate ventilation to avoid inhalation of dust. Waste disposal must comply with hazardous chemical regulations. APPLICATIONS: 1-chloro-7-fluoroisoquinoline serves as a versatile intermediate in pharmaceutical synthesis, particularly for developing kinase inhibitors and anticancer agents due to its halogenated isoquinoline scaffold. Its reactivity in cross-coupling reactions enables the introduction of diverse functional groups, as highlighted in medicinal chemistry research by AstraZeneca. Additionally, it is explored in materials science for constructing fluorinated aromatic frameworks in organic electronics, as reported in Advanced Functional Materials studies.
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