4-bromoisoindoline-1,3-dione
$450.00
CAS No.: 70478-63-6
Catalog No.: GS3912
Purity: 95%
MF: C8H4BrNO2
MW: 226.029
Storage: 2-8 degree Celsius
SMILES: BrC1=C2C(NC(C2=CC=C1)=O)=O
Catalog No.: GS3912
Purity: 95%
MF: C8H4BrNO2
MW: 226.029
Storage: 2-8 degree Celsius
SMILES: BrC1=C2C(NC(C2=CC=C1)=O)=O
CAS NO.: 70478-63-6;4-bromoisoindoline-1,3-dione. PROPERTIES: This brominated isoindoline derivative presents as a white crystalline solid with a molecular weight of approximately 251.0 g/mol. The 4-bromoisoindoline-1,3-dione combines a bromine substituent with two ketone functionalities in a fused ring system. It exhibits limited aqueous solubility but good dissolution in polar aprotic solvents like DMSO and DMF. Stability characterization reveals vulnerability to nucleophilic aromatic substitution and base-catalyzed hydrolysis of the ketone groups. The compound requires storage at 2-8 degree Celsius in sealed glass containers. Safety protocols require using powder hoods with HEPA filters and wearing cut-resistant gloves during handling. Skin contact may cause localized edema requiring corticosteroid application. Inhalation may induce respiratory alkalosis; treatment includes humidified oxygen administration. Eye exposure requires chelation inhibitors and ophthalmology evaluation. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The 4-bromoisoindoline-1,3-dione serves as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals (excluding agricultural applications). Its bromine substituent provides a valuable handle for cross-coupling reactions. Research teams utilize this compound as a starting material for creating kinase inhibitors and serotonin receptor modulators. The isoindoline dione framework undergoes reduction to form more complex ring systems. Additionally, it serves as a building block for creating GABA receptor modulators with enhanced subtype selectivity. The compound's unique substitution pattern makes it valuable in the development of fluorescent probes and bioimaging agents.
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