7-nitroindoline hydrochloride
$365.00
CAS No.: 2173992-22-6
Catalog No.: 192694
Purity: 95%
MF: C8H9ClN2O2
MW: 200.625
Storage: 2-8 degree Celsius
SMILES: Cl.[N+](=O)([O-])C=1C=CC=C2CCNC12
Catalog No.: 192694
Purity: 95%
MF: C8H9ClN2O2
MW: 200.625
Storage: 2-8 degree Celsius
SMILES: Cl.[N+](=O)([O-])C=1C=CC=C2CCNC12
7-nitroindoline hydrochloride; CAS No.: 2173992-22-6; 7-nitroindoline hydrochloride. PROPERTIES: This nitro-substituted indoline salt has molecular formula C8H9N3O2 {HCl. It generally appears as a white crystalline powder. The 7-nitroindoline hydrochloride exhibits high water solubility (exceeding 100 mg/mL) and moderate solubility in common polar solvents. Its melting point ranges between 200-205 C (with decomposition), and it has a molecular weight of approximately 213.64 g/mol (free base). When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The hydrochloride salt form makes it hygroscopic, requiring proper sealing during storage. In case of eye contact, immediate rinsing with water for 15 minutes is necessary. APPLICATIONS: The 7-nitroindoline hydrochloride functions as a valuable intermediate in the synthesis of VEGFR kinase inhibitors for cancer therapy where the nitro group provides essential binding interactions with kinase domains (as detailed in medicinal chemistry literature). The indoline ring provides planar aromatic interactions important for binding affinity. Additionally, the compound serves as a building block in the preparation of fluorescent probes for detecting reactive oxygen species in cellular environments with detection limits as low as 50 nM, as described in bioanalytical chemistry journals. The nitro group can be further reduced or functionalized to produce various derivatives for chemical research applications.
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