6-methyl-1H-indole-5-carboxamide
$180.00
CAS No.: 2665662-91-7
Catalog No.: 192677
Purity: 95%
MF: C10H10N2O
MW: 174.203
Storage: 2-8 degree Celsius
SMILES: CC1=C(C=C2C=CNC2=C1)C(=O)N
Catalog No.: 192677
Purity: 95%
MF: C10H10N2O
MW: 174.203
Storage: 2-8 degree Celsius
SMILES: CC1=C(C=C2C=CNC2=C1)C(=O)N
6-methyl-1H-indole-5-carboxamide; CAS No.: 2665662-91-7; 6-methyl-1H-indole-5-carboxamide. PROPERTIES: This methylated indole carboxamide has molecular formula C10H9N3O. It generally appears as a white crystalline powder. The 6-methyl-1H-indole-5-carboxamide exhibits limited water solubility but good solubility in DMSO and DMF. Its melting point ranges between 180-185 C, and it has a molecular weight of approximately 183.19 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong acids and may hydrolyze to the corresponding carboxylic acid upon exposure to aqueous conditions. In case of spillage, absorb with inert material and dispose of in accordance with local regulations. APPLICATIONS: The 6-methyl-1H-indole-5-carboxamide serves as a valuable intermediate in the synthesis of dual orexin receptor antagonists for insomnia treatment where the carboxamide group provides essential hydrogen bonding interactions with receptor subtypes (as detailed in medicinal chemistry literature). The methyl group enhances metabolic stability by preventing oxidative degradation. Additionally, the compound functions as a building block in the preparation of fluorescent probes for detecting protein kinase activity in cellular environments with detection limits as low as 10 nM, as described in bioanalytical chemistry journals. The carboxamide group can be further functionalized through hydrolysis or amidation reactions to produce various derivatives for chemical research applications.
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