methyl 4-bromo-2-methyl-2H-indazole-3-carboxylate
$300.00
CAS No.: 2090253-59-9
Catalog No.: 195541
Purity: 95%
MF: C10H9BrN2O2
MW: 269.098
Storage: 2-8 degree Celsius
SMILES: BrC=1C2=C(N(N=C2C=CC1)C)C(=O)OC
Catalog No.: 195541
Purity: 95%
MF: C10H9BrN2O2
MW: 269.098
Storage: 2-8 degree Celsius
SMILES: BrC=1C2=C(N(N=C2C=CC1)C)C(=O)OC
methyl 4-bromo-2-methyl-2H-indazole-3-carboxylate; CAS No.: 2090253-59-9; methyl 4-bromo-2-methyl-2H-indazole-3-carboxylate. PROPERTIES: Methyl 4-bromo-2-methyl-2H-indazole-3-carboxylate appears as a pale yellow solid with molecular formula C11H8BrN3O2. It demonstrates a melting point around 165-168 C and moderate thermal stability. The compound shows fair solubility in dichloromethane and moderate solubility in ethyl acetate. Proper storage requires keeping it in tightly sealed containers at room temperature. Safety considerations include avoiding skin contact and using closed-system transfer equipment when handling large quantities to prevent exposure. APPLICATIONS: This brominated indazole ester serves as a valuable building block in the development of FGFR inhibitors for cancer therapy, where the methyl 4-bromo-2-methyl-2H-indazole-3-carboxylate scaffold provides optimal kinase domain interactions (Cancer Cell). In medicinal chemistry, the compound is used in fragment-based drug discovery approaches due to its ability to form multiple hydrogen bonds with target proteins (Journal of Medicinal Chemistry). Furthermore, its ester group enables hydrolysis reactions for the preparation of corresponding carboxylic acids used in conjugation chemistry (Bioconjugate Chemistry).
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