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CAS No.: 677305-02-1; Facinicline hydrochloride. PROPERTIES: Facinicline hydrochloride is a white crystalline powder with a molecular weight of approximately 348.9 g/mol. Its chemical formula is C16H20ClN5O. The compound is freely soluble in water and ethanol. It should be stored at room temperature in airtight containers protected from light. Stability is maintained for at least one year under proper conditions. Safety precautions include avoiding inhalation of dust and using PPE during handling. The substance is harmful if swallowed and may cause serious eye irritation. APPLICATIONS: Facinicline hydrochloride is a potent and selective antagonist of the nicotinic acetylcholine receptor 4 2 subtype. It is primarily investigated for the treatment of nicotine addiction and smoking cessation. Clinical trials indicate its ability to reduce nicotine cravings and withdrawal symptoms. The compound has also been explored in cognitive disorders related to nicotinic receptor dysfunction. Additionally, Facinicline hydrochloride serves as a research tool for studying the role of 4 2 receptors in neurological conditions. These applications are supported by clinical study reports and pharmacology research publications focusing on addiction medicine and neuroscience.