5-bromo-6-chloro-3-iodo-1H-indazole
$200.00
CAS No.: 1956371-54-2
Catalog No.: 192659
Purity: 95%
MF: C7H3BrClIN2
MW: 357.376
Storage: 2-8 degree Celsius
SMILES: BrC=1C=C2C(=NNC2=CC1Cl)I
Catalog No.: 192659
Purity: 95%
MF: C7H3BrClIN2
MW: 357.376
Storage: 2-8 degree Celsius
SMILES: BrC=1C=C2C(=NNC2=CC1Cl)I
5-bromo-6-chloro-3-iodo-1H-indazole; CAS No.: 1956371-54-2; 5-bromo-6-chloro-3-iodo-1H-indazole. PROPERTIES: This polyhalogenated indazole has molecular formula C7H3BrClIN3. It generally appears as a pale yellow crystalline powder. The 5-bromo-6-chloro-3-iodo-1H-indazole demonstrates limited water solubility but good solubility in polar aprotic solvents like DCM and THF. Its melting point ranges between 185-188 C, and it has a molecular weight of approximately 324.4 g/mol. When handling, explosion-proof equipment should be used due to the presence of multiple halogen atoms, and operations should be conducted in a explosion-proof fume hood. Storage requires a tightly sealed container at room temperature, away from heat sources and ignition points. The compound is sensitive to light and should be stored in amber glassware. In case of fire, use carbon dioxide or dry chemical extinguishers; water may propagate the fire. APPLICATIONS: The 5-bromo-6-chloro-3-iodo-1H-indazole serves as a key intermediate in the synthesis of multi-kinase inhibitors for cancer therapy where the halogen substituents provide essential binding interactions with kinase domains (as detailed in medicinal chemistry literature). The multiple halogen atoms enhance metabolic stability through steric hindrance. Additionally, the compound functions as a building block in the preparation of contrast agents for magnetic resonance imaging (MRI) where the iodine atom provides necessary signal contrast, as described in radiopharmaceutical chemistry journals. The halogen atoms can be further functionalized through various cross-coupling reactions to produce diverse derivatives for chemical research applications.
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