3-methyl-1H-indazole-7-carbonitrile
$365.00
CAS No.: 1554584-26-7
Catalog No.: 195543
Purity: 95%
MF: C9H7N3
MW: 157.176
Storage: 2-8 degree Celsius
SMILES: CC1=NNC2=C(C=CC=C12)C#N
Catalog No.: 195543
Purity: 95%
MF: C9H7N3
MW: 157.176
Storage: 2-8 degree Celsius
SMILES: CC1=NNC2=C(C=CC=C12)C#N
3-methyl-1H-indazole-7-carbonitrile; CAS No.: 1554584-26-7; 3-methyl-1H-indazole-7-carbonitrile. PROPERTIES: 3-methyl-1H-indazole-7-carbonitrile is a crystalline compound with molecular formula C10H7N3. It exhibits a melting point around 155-158 C and moderate thermal stability. The compound shows good solubility in DMF and moderate solubility in THF. Recommended storage conditions include keeping it in tightly sealed containers at room temperature. Safety considerations involve using explosion-proof equipment when handling in combustible solvent systems due to potential flammability and avoiding inhalation of dust particles. APPLICATIONS: This methylated indazole nitrile serves as a valuable intermediate in the development of JAK inhibitors for inflammatory disease treatment, where the 3-methyl-1H-indazole-7-carbonitrile group facilitates selective binding to the kinase domain (Journal of Medicinal Chemistry). In materials science, the compound is incorporated into organic semiconductors as an electron-transporting material due to its electron-deficient nitrile group (Advanced Functional Materials). Additionally, its nitrile functionality enables hydrolysis reactions for the preparation of corresponding carboxylic acids used in medicinal chemistry library development (Bioorganic & Medicinal Chemistry Letters).
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