3-bromo-6-methyl-1H-indazol-5-amine
$250.00
CAS No.: 1000343-43-0
Catalog No.: 192643
Purity: 95%
MF: C8H8BrN3
MW: 226.077
Storage: 2-8 degree Celsius
SMILES: BrC1=NNC2=CC(=C(C=C12)N)C
Catalog No.: 192643
Purity: 95%
MF: C8H8BrN3
MW: 226.077
Storage: 2-8 degree Celsius
SMILES: BrC1=NNC2=CC(=C(C=C12)N)C
3-bromo-6-methyl-1H-indazol-5-amine; CAS No.: 1000343-43-0; 3-bromo-6-methyl-1H-indazol-5-amine. PROPERTIES: This brominated indazole derivative has molecular formula C9H8BrN3. It generally appears as an orange-brown crystalline solid. The 3-bromo-6-methyl-1H-indazol-5-amine exhibits limited solubility in water but good solubility in DMSO and DMF. Its melting point ranges between 185-190 C, and it has a molecular weight of approximately 252.09 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection due to potential sensitization. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong bases and may decompose upon exposure to high temperatures above 200 C. In case of eye contact, immediate rinsing with water for 15 minutes is necessary. APPLICATIONS: The 3-bromo-6-methyl-1H-indazol-5-amine serves as a valuable intermediate in the synthesis of VEGFR inhibitors for cancer therapy where the bromine atom provides essential binding interactions with kinase domains (as detailed in medicinal chemistry literature). The methyl group enhances lipophilicity, improving cell membrane permeability. Additionally, the compound functions as a precursor in the preparation of fluorescent probes for detecting zinc ions in biological systems with detection limits as low as 100 nM, as described in bioinorganic chemistry publications. The amine group can be further modified through acylation or sulfonamidation to produce derivatives with varied biological activities for drug discovery research.
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