1-(1-methyl-1H-indazol-7-yl)ethanone
$300.00
CAS No.: 1159511-26-8
Catalog No.: 196194
Purity: 95%
MF: C10H10N2O
MW: 174.203
Storage: 2-8 degree Celsius
SMILES: CN1N=CC2=CC=CC(=C12)C(C)=O
Catalog No.: 196194
Purity: 95%
MF: C10H10N2O
MW: 174.203
Storage: 2-8 degree Celsius
SMILES: CN1N=CC2=CC=CC(=C12)C(C)=O
1-(1-methyl-1H-indazol-7-yl)ethanone; CAS No.: 1159511-26-8; 1-(1-methyl-1H-indazol-7-yl)ethanone. PROPERTIES: This compound presents a 1-(1-methyl-1H-indazol-7-yl)ethanone structure, combining an acetone group and a methyl-substituted indazole ring system. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 195.2 g/mol (C12H11N3O). The melting point ranges between 145-150 C, and it exhibits moderate solubility in common organic solvents like ethanol, methanol, and DMSO while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing gloves, eye protection, and a lab coat. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 1-(1-Methyl-1H-indazol-7-yl)ethanone serves as a specialized intermediate in pharmaceutical research. Its 1-(1-methyl-1H-indazol-7-yl)ethanone structure enables participation in various reactions, including nucleophilic addition at the ketone carbonyl and electrophilic substitution at the indazole ring. In medicinal chemistry, it is used to develop enzyme inhibitors and receptor modulators, particularly those targeting kinases and proteases. The ketone group can be reduced to secondary alcohol or undergo condensation reactions to form Schiff bases. This compound also functions as a building block in the synthesis of fluorescent probes for bioimaging applications, where the indazole moiety contributes to fluorescence properties. Academic studies utilize it as a model system in Medicinal Chemistry journals, focusing on optimizing the 1-(1-methyl-1H-indazol-7-yl)ethanone scaffold for improved biological activity and target engagement.
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