4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-1-methyl-1H-imidazole-2-carboxylic acid
$400.00
CAS No.: 252206-28-3
Catalog No.: 196821
Purity: 95%
MF: C20H17N3O4
MW: 363.373
Storage: 2-8 degree Celsius
SMILES: C1=CC=CC=2C3=CC=CC=C3C(C12)COC(=O)NC=1N=C(N(C1)C)C(=O)O
Catalog No.: 196821
Purity: 95%
MF: C20H17N3O4
MW: 363.373
Storage: 2-8 degree Celsius
SMILES: C1=CC=CC=2C3=CC=CC=C3C(C12)COC(=O)NC=1N=C(N(C1)C)C(=O)O
4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-1-methyl-1H-imidazole-2-carboxylic acid; CAS No.: 252206-28-3; 4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-1-methyl-1H-imidazole-2-carboxylic acid. PROPERTIES: This Fmoc-protected imidazole carboxylic acid features molecular formula C??H??N?O? with molecular weight 352.34 g/mol. It typically exists as a white crystalline powder. Soluble in polar aprotic solvents like DMF and DMSO. Melting point approximately 140-145 C. Exhibits IR absorption for carboxylic acid (~2900-2500 cm??) and ester groups (~1750 cm??). Thermogravimetric analysis indicates decomposition above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause mild skin irritation and serious eye damage; therefore, standard laboratory safety precautions including protective clothing and eye protection are recommended during handling. APPLICATIONS: As an Fmoc-protected imidazole carboxylic acid, 4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-1-methyl-1H-imidazole-2-carboxylic acid is predominantly utilized in the synthesis of peptide-based therapeutics. It serves as a key building block for constructing bioactive peptides with enhanced conformational stability, particularly in the development of enzyme inhibitors targeting proteases (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its carboxylic acid functionality enables conjugation to biomolecules via amide bond formation (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyimide polymers with enhanced thermal stability, where the Fmoc group provides valuable solubility properties (Polymer Chemistry).
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