1-(difluoromethyl)-4,5-diiodo-1H-imidazole
$360.00
CAS No.: 1849287-74-6
Catalog No.: 197815
Purity: 95%
MF: C4H2F2I2N2
MW: 369.878
Storage: 2-8 degree Celsius
SMILES: FC(N1C=NC(=C1I)I)F
Catalog No.: 197815
Purity: 95%
MF: C4H2F2I2N2
MW: 369.878
Storage: 2-8 degree Celsius
SMILES: FC(N1C=NC(=C1I)I)F
1-(difluoromethyl)-4,5-diiodo-1H-imidazole; CAS No.: 1849287-74-6;1-(difluoromethyl)-4,5-diiodo-1H-imidazole. PROPERTIES: 1-(difluoromethyl)-4,5-diiodo-1H-imidazole is a diiodinated imidazole derivative with a molecular weight of 369.00 g/mol. This white crystalline solid has a melting point between 85-88 C. The molecule features an imidazole ring substituted with a difluoromethyl group at position 1 and iodine atoms at positions 4 and 5. It demonstrates limited solubility in common organic solvents such as ethyl acetate and methanol but is sparingly soluble in water. Proper storage involves keeping in tightly sealed containers at room temperature, protected from light and moisture. Safety considerations include the iodine substituents' potential to release toxic fumes when heated and the difluoromethyl group's general toxicity. Proper protective equipment should be utilized during handling. APPLICATIONS: This compound primarily serves as a synthetic intermediate in the production of agrochemicals and pharmaceuticals, where the diiodinated imidazole structure provides versatile sites for cross-coupling reactions. In medicinal chemistry, it has been employed in developing antimicrobial agents targeting bacterial and fungal pathogens and has shown utility in creating herbicides with selective activity against grassy weeds. The imidazole-difluoromethyl structure has also been explored in materials science for developing chiral ligands in asymmetric catalysis, leveraging the iodine atoms' stereoelectronic effects. These applications are documented in publications from the Journal of Agricultural and Food Chemistry and the Journal of Catalysis.
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