N-((1,4-dioxan-2-yl)methyl)benzamide
$275.00
CAS No.: 1378454-64-8
Catalog No.: 192716
Purity: 95%
MF: C12H15NO3
MW: 221.256
Storage: 2-8 degree Celsius
SMILES: O1C(COCC1)CNC(C1=CC=CC=C1)=O
Catalog No.: 192716
Purity: 95%
MF: C12H15NO3
MW: 221.256
Storage: 2-8 degree Celsius
SMILES: O1C(COCC1)CNC(C1=CC=CC=C1)=O
N-((1,4-dioxan-2-yl)methyl)benzamide; CAS No.: 1378454-64-8; N-((1,4-dioxan-2-yl)methyl)benzamide. PROPERTIES: This dioxane-substituted benzamide has molecular formula C12H13NO3. It typically appears as a white crystalline powder. The N-((1,4-dioxan-2-yl)methyl)benzamide demonstrates limited water solubility but good solubility in common organic solvents like methanol and ethyl acetate. Its melting point ranges between 120-125 C, and it has a molecular weight of approximately 223.24 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong acids and may hydrolyze to the corresponding carboxylic acid upon exposure to aqueous conditions. In case of spillage, absorb with inert material and dispose of in accordance with local regulations. APPLICATIONS: The N-((1,4-dioxan-2-yl)methyl)benzamide functions as a valuable intermediate in the synthesis of serotonin receptor antagonists for psychiatric disorders where the dioxane group provides essential lipophilicity for blood-brain barrier penetration (as detailed in medicinal chemistry literature). The benzamide group forms hydrogen bonds with receptor residues. Additionally, the compound serves as a building block in the preparation of liquid crystal materials with specific elastic constants, useful in display technologies with response times below 20 milliseconds as described in materials chemistry journals. The amide group can be further functionalized through hydrolysis or amidation reactions to produce various derivatives for chemical research applications.
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