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2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine
$300.00
CAS No.: 117890-55-8
Catalog No.: 196193
Purity: 95%
MF: C8H8ClN
MW: 153.612
Storage: 2-8 degree Celsius
SMILES: ClC1=CC=C2C(=N1)CCC2
Catalog No.: 196193
Purity: 95%
MF: C8H8ClN
MW: 153.612
Storage: 2-8 degree Celsius
SMILES: ClC1=CC=C2C(=N1)CCC2
2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine; CAS No.: 117890-55-8; 2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine. PROPERTIES: This compound features a 2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine structure, combining a chloro group and a partially hydrogenated cyclopenta[b]pyridine framework. It typically appears as a colorless to pale yellow liquid with a molecular weight of approximately 163.6 g/mol (C9H9ClN). The density is around 1.2 g/cm?, and it has a boiling point of approximately 190-195 C at 760 mmHg. It exhibits moderate solubility in common organic solvents like ethyl acetate, dichloromethane, and tetrahydrofuran while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety precautions include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 2-Chloro-6,7-dihydro-5H-cyclopenta[b]pyridine serves as a valuable intermediate in pharmaceutical and chemical synthesis. Its 2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine structure enables diverse reactivity patterns, including nucleophilic substitution at the chloro position and hydrogenation/dehydrogenation reactions at the dihydro portion. In medicinal chemistry, it is used to develop bioactive molecules targeting the central nervous system and inflammatory pathways. The chloro group can be displaced to introduce amine or alcohol substituents. This compound also functions as a building block in the synthesis of agrochemicals (though agricultural applications are excluded here). Academic studies employ it as a model system in Organic Chemistry journals, focusing on the development of novel cyclopentapyridine derivatives based on the 2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine scaffold.
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