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2-chloro-4,6-difluorobenzo[d]thiazole
$250.00
CAS No.: 252681-57-5
Catalog No.: 196166
Purity: 95%
MF: C7H2ClF2NS
MW: 205.616
Storage: 2-8 degree Celsius
SMILES: ClC=1SC2=C(N1)C(=CC(=C2)F)F
Catalog No.: 196166
Purity: 95%
MF: C7H2ClF2NS
MW: 205.616
Storage: 2-8 degree Celsius
SMILES: ClC=1SC2=C(N1)C(=CC(=C2)F)F
2-chloro-4,6-difluorobenzo[d]thiazole; CAS No.: 252681-57-5; 2-chloro-4,6-difluorobenzo[d]thiazole. PROPERTIES: This compound features a 2-chloro-4,6-difluorobenzo[d]thiazole structure with multiple halogen substituents on the benzo[d]thiazole framework. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 220.5 g/mol (C8H3ClF2NS). The melting point ranges between 100-105 C, and it exhibits moderate solubility in common organic solvents like DMSO, DMF, and dichloromethane while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include using appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 2-Chloro-4,6-difluorobenzo[d]thiazole serves as a valuable intermediate in pharmaceutical and chemical synthesis. Its 2-chloro-4,6-difluorobenzo[d]thiazole structure allows for diverse substitution patterns, making it suitable for developing bioactive molecules through palladium-catalyzed cross-coupling reactions. In medicinal chemistry, it is used to create kinase inhibitors and antimicrobial agents by introducing various substituents at the chloro position. The fluorine atoms provide metabolic stability and favorable binding interactions with biological targets. This compound also functions as a building block in the synthesis of liquid crystals and organic electronics, where the benzo[d]thiazole moiety contributes to -conjugation. Academic research employs it as a starting material in Organic Chemistry journals, focusing on the development of novel fluorinated heterocycles based on the 2-chloro-4,6-difluorobenzo[d]thiazole scaffold.
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