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2-(6-fluoro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetic acid
$350.00
CAS No.: 767305-43-1
Catalog No.: LT0028
Purity: 95%
MF: C9H7FN2O3
MW: 210.164
Storage: 2-8 degree Celsius
SMILES: FC=1C=CC2=C(N(C(N2)=O)CC(=O)O)C1
Catalog No.: LT0028
Purity: 95%
MF: C9H7FN2O3
MW: 210.164
Storage: 2-8 degree Celsius
SMILES: FC=1C=CC2=C(N(C(N2)=O)CC(=O)O)C1
CAS NO.: 767305-43-1;2-(6-fluoro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetic acid. PROPERTIES: This fluorinated imidazole derivative presents as a white crystalline solid with a molecular weight of approximately 217.1 g/mol. The 2-(6-fluoro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetic acid combines a fluorinated benzimidazole framework with an acetic acid substituent. It exhibits limited aqueous solubility but good dissolution in polar aprotic solvents like DMSO and DMF. Stability characterization reveals vulnerability to acid-catalyzed ring-opening and base-promoted hydrolysis of the carboxylic acid group, necessitating storage at 2-8 degree Celsius in sealed glass containers. Handlers should use powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause localized edema requiring corticosteroid application. Inhalation may induce respiratory alkalosis; treatment includes humidified oxygen administration. Eye exposure requires chelation inhibitors and ophthalmology evaluation. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The 2-(6-fluoro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetic acid serves as a key intermediate in the synthesis of various pharmaceuticals. Its benzimidazole framework provides opportunities for directed metalation and cross-coupling reactions. Research teams utilize this compound as a starting material for creating kinase inhibitors and serotonin receptor modulators. The fluorine substituent enhances metabolic resistance in resulting drug candidates. Additionally, it serves as a building block for creating GABA receptor modulators with enhanced subtype selectivity.
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