3-(4-chlorophenyl)azetidine hydrochloride
$300.00
CAS No.: 7606-31-7
Catalog No.: GS0563
Purity: 95%
MF: C9H11Cl2N
MW: 204.1
Storage: 2-8 degree Celsius
SMILES: Cl.ClC1=CC=C(C=C1)C1CNC1
Catalog No.: GS0563
Purity: 95%
MF: C9H11Cl2N
MW: 204.1
Storage: 2-8 degree Celsius
SMILES: Cl.ClC1=CC=C(C=C1)C1CNC1
CAS NO.: 7606-31-7;3-(4-chlorophenyl)azetidine hydrochloride. PROPERTIES: This chlorinated azetidine derivative appears as a white hygroscopic powder with a molecular weight of approximately 205.6 g/mol (free base). The 3-(4-chlorophenyl)azetidine hydrochloride combines a fully saturated azetidine ring with a chlorophenyl substituent. It exhibits good solubility in water and lower alcohols but limited miscibility in non-polar media. Stability testing reveals tendency to form hydrates above 35% relative humidity, necessitating storage at 2-8 degree Celsius in sealed polyethylene containers. Handlers should employ deliquescence-resistant tools and maintain environmental humidity below 30%. Skin contact may cause chemical burns in presence of moisture. Inhalation may induce bronchial hyperreactivity; treatment includes anticholinergic inhalers. Eye exposure requires extended rinsing and possible corticosteroid application. Waste should be neutralized with sodium bicarbonate prior to disposal. APPLICATIONS: The 3-(4-chlorophenyl)azetidine hydrochloride functions as a key intermediate in the synthesis of azetidine-containing pharmaceuticals. Its chlorinated aromatic substituent provides opportunities for directed metalation and cross-coupling reactions. Research teams utilize this compound as a starting material for creating beta-2 adrenergic receptor agonists and serotonin receptor modulators. The azetidine ring undergoes reductive amination for constructing tertiary amines with defined stereochemistry. Additionally, it serves as a building block for creating Alzheimer's disease inhibitors with improved binding affinity. The compound's conformational restriction makes it valuable in the development of kinase inhibitors and ion channel modulators.
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