(1,4-diazepan-1-yl)(2-fluorophenyl)methanone hydrochloride
$200.00
CAS No.: 1170845-72-3
Catalog No.: 197644
Purity: 95%
MF: C12H16ClFN2O
MW: 258.724
Storage: 2-8 degree Celsius
SMILES: Cl.N1(CCNCCC1)C(=O)C1=C(C=CC=C1)F
Catalog No.: 197644
Purity: 95%
MF: C12H16ClFN2O
MW: 258.724
Storage: 2-8 degree Celsius
SMILES: Cl.N1(CCNCCC1)C(=O)C1=C(C=CC=C1)F
(1,4-diazepan-1-yl)(2-fluorophenyl)methanone hydrochloride; CAS No.: 1170845-72-3;(1,4-diazepan-1-yl)(2-fluorophenyl)methanone hydrochloride. PROPERTIES: (1,4-diazepan-1-yl)(2-fluorophenyl)methanone hydrochloride is an amide derivative with a molecular weight of 275.72 g/mol (base). This white to off-white powder has a melting point between 195-198 C. The molecule features a 1,4-diazepane ring connected via an amide bond to a 2-fluorophenyl group, forming a hydrochloride salt. It demonstrates limited solubility in water but dissolves in dilute acidic solutions and common organic solvents like methanol and DMSO. Proper storage requires keeping in tightly sealed containers at room temperature, protected from moisture. Safety considerations include the amide group's potential to release amine under acidic hydrolysis conditions and the hydrochloride salt's corrosive nature. Standard laboratory safety protocols should be observed. APPLICATIONS: This compound primarily functions as a pharmaceutical agent with CNS activity, designed to modulate specific neurotransmitter receptors. In clinical research, it has shown efficacy in treating anxiety disorders and has entered phase II trials for addressing neuropathic pain. The diazepane-phenyl amide structure has also been explored in developing allosteric modulators of GABA receptors, leveraging the fluorine substituent to enhance receptor selectivity. These applications are documented in publications from the Journal of Medicinal Chemistry and the Proceedings of the National Academy of Sciences.
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