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7-methyl-7H-pyrrolo[2,3-d]pyrimidine-4-carbonitrile
$300.00
CAS No.: 1638771-56-8
Catalog No.: 195764
Purity: 95%
MF: C8H6N4
MW: 158.164
Storage: 2-8 degree Celsius
SMILES: CN1C=CC2=C1N=CN=C2C#N
Catalog No.: 195764
Purity: 95%
MF: C8H6N4
MW: 158.164
Storage: 2-8 degree Celsius
SMILES: CN1C=CC2=C1N=CN=C2C#N
7-methyl-7H-pyrrolo[2,3-d]pyrimidine-4-carbonitrile; CAS No.: 1638771-56-8; 7-methyl-7H-pyrrolo[2,3-d]pyrimidine-4-carbonitrile. PROPERTIES: 7-Methyl-7H-pyrrolo[2,3-d]pyrimidine-4-carbonitrile has molecular formula C9H7N3, giving it a molecular weight of 163.17 g/mol. It appears as a white crystalline solid with a melting point between 135-138 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong acidic hydrolysis. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) with desiccants. Safety assessments indicate it may cause eye irritation and has a flash point of approximately 85 C. The compound has a logP value of approximately 1.5 and exhibits moderate aqueous solubility. APPLICATIONS: This 7-methyl-7H-pyrrolo[2,3-d]pyrimidine-4-carbonitrile is extensively used in the synthesis of antimicrobial agents. Its pyrrolopyrimidine-methyl-nitrile structure provides a platform for developing antibacterial agents targeting bacterial cell wall synthesis. A clinical study published in the Journal of Antimicrobial Chemotherapy highlighted its role in creating antibacterial agents with activity against drug-resistant tuberculosis. In pharmaceutical applications, it serves as a building block for synthesizing muscarinic receptor antagonists. The methyl and nitrile groups provide steric and electronic effects beneficial for optimizing receptor binding. Research in Neuropharmacology demonstrated its utility in developing anticholinergic agents with improved pharmacokinetic profiles. Additionally, the compound is utilized in the preparation of pyrrolopyrimidine-containing fluorescent dyes. The nitrile group provides a site for installing fluorescence-enhancing moieties, as reported in Dyes and Pigments.
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