5-iodopyrimidin-2-ol
$300.00
CAS No.: 79387-69-2
Catalog No.: 196421
Purity: 95%
MF: C4H3IN2O
MW: 221.985
Storage: 2-8 degree Celsius
SMILES: IC=1C=NC(=NC1)O
Catalog No.: 196421
Purity: 95%
MF: C4H3IN2O
MW: 221.985
Storage: 2-8 degree Celsius
SMILES: IC=1C=NC(=NC1)O
5-iodopyrimidin-2-ol; CAS No.: 79387-69-2; 5-iodopyrimidin-2-ol. PROPERTIES: This compound presents a 5-iodopyrimidin-2-ol structure, combining an iodine atom and a hydroxyl group on the pyrimidine framework. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 259.0 g/mol (C4H3IN2O). The melting point ranges between 150-155 C, and it exhibits moderate solubility in common organic solvents like DMSO and DMF while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 5-Iodopyrimidin-2-ol serves as a specialized intermediate in pharmaceutical research. Its 5-iodopyrimidin-2-ol structure enables diverse reactivity patterns, including palladium-catalyzed cross-coupling reactions at the iodine position and hydrogen bonding interactions through the hydroxyl group. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The iodine atom provides a highly reactive handle for introducing aryl, vinyl, or heterocyclic substituents. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies utilize it as a model system in Medicinal Chemistry journals, focusing on optimizing the 5-iodopyrimidin-2-ol scaffold for improved biological activity and pharmacokinetic properties.
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