4-(dimethoxymethyl)-2-methylpyrimidine
$200.00
CAS No.: 175277-33-5
Catalog No.: 196419
Purity: 95%
MF: C8H12N2O2
MW: 168.196
Storage: 2-8 degree Celsius
SMILES: COC(C1=NC(=NC=C1)C)OC
Catalog No.: 196419
Purity: 95%
MF: C8H12N2O2
MW: 168.196
Storage: 2-8 degree Celsius
SMILES: COC(C1=NC(=NC=C1)C)OC
4-(dimethoxymethyl)-2-methylpyrimidine; CAS No.: 175277-33-5; 4-(dimethoxymethyl)-2-methylpyrimidine. PROPERTIES: This compound presents a 4-(dimethoxymethyl)-2-methylpyrimidine structure, combining a dimethoxymethyl group and a methyl substituent on the pyrimidine framework. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 179.2 g/mol (C7H10N2O2). The melting point ranges between 70-75 C, and it exhibits moderate solubility in common organic solvents like ethyl acetate, dichloromethane, and tetrahydrofuran while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 4-(Dimethoxymethyl)-2-methylpyrimidine serves as a specialized intermediate in pharmaceutical research. Its 4-(dimethoxymethyl)-2-methylpyrimidine structure enables diverse reactivity patterns, including nucleophilic substitution at the pyrimidine ring and hydrolysis of the dimethoxymethyl group to carboxylic acid. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The dimethoxymethyl group provides steric and electronic effects that influence binding interactions with biological targets. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies utilize it as a model system in Medicinal Chemistry journals, focusing on optimizing the 4-(dimethoxymethyl)-2-methylpyrimidine scaffold for improved biological activity and pharmacokinetic properties.
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