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3-bromopyridazine
$300.00
CAS No.: 88491-61-6
Catalog No.: 196372
Purity: 95%
MF: C4H3BrN2
MW: 158.986
Storage: 2-8 degree Celsius
SMILES: BrC=1N=NC=CC1
Catalog No.: 196372
Purity: 95%
MF: C4H3BrN2
MW: 158.986
Storage: 2-8 degree Celsius
SMILES: BrC=1N=NC=CC1
3-bromopyridazine; CAS No.: 88491-61-6; 3-bromopyridazine. PROPERTIES: This compound features a 3-bromopyridazine structure, combining a bromine atom and a pyridazine ring system. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 157.0 g/mol (C4H3BrN2). The melting point ranges between 70-75 C, and it exhibits moderate solubility in common organic solvents like DMSO and DMF while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 3-Bromopyridazine serves as a versatile intermediate in pharmaceutical and chemical synthesis. Its 3-bromopyridazine structure allows for participation in various reactions, including palladium-catalyzed cross-coupling reactions at the bromine position and nucleophilic substitution at the pyridazine ring. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The bromine atom provides a handle for introducing aryl, vinyl, or heterocyclic substituents. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies employ it as a model compound in Organic Chemistry journals, focusing on the development of novel bromopyridazine derivatives based on the 3-bromopyridazine scaffold.
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