2-phenyl-2-(piperidin-2-yl)acetic acid
$300.00
CAS No.: 19395-41-6
Catalog No.: 196313
Purity: 95%
MF: C13H17NO2
MW: 219.284
Storage: 2-8 degree Celsius
SMILES: C1(=CC=CC=C1)C(C(=O)O)C1NCCCC1
Catalog No.: 196313
Purity: 95%
MF: C13H17NO2
MW: 219.284
Storage: 2-8 degree Celsius
SMILES: C1(=CC=CC=C1)C(C(=O)O)C1NCCCC1
2-phenyl-2-(piperidin-2-yl)acetic acid; CAS No.: 19395-41-6; 2-phenyl-2-(piperidin-2-yl)acetic acid. PROPERTIES: This compound presents a 2-phenyl-2-(piperidin-2-yl)acetic acid structure, combining a phenyl group, a piperidine ring, and a carboxylic acid group. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 227.2 g/mol (C14H17NO2). The melting point ranges between 130-135 C, and it exhibits moderate solubility in common organic solvents like ethanol, methanol, and DMSO while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 2-Phenyl-2-(piperidin-2-yl)acetic acid serves as a specialized intermediate in pharmaceutical research. Its 2-phenyl-2-(piperidin-2-yl)acetic acid structure enables diverse reactivity patterns, including esterification, amide bond formation, and nucleophilic substitution at the piperidine nitrogen. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The phenyl group provides additional conjugation that enhances binding to biological targets. This compound also functions as a building block in the synthesis of bioactive peptides and depsipeptides. Academic studies employ it as a model system in Medicinal Chemistry journals, focusing on optimizing the 2-phenyl-2-(piperidin-2-yl)acetic acid scaffold for improved biological activity and target engagement.
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