(2-methoxyphenyl)(piperazin-1-yl)methanone hydrochloride
$350.00
CAS No.: 100939-98-8
Catalog No.: GS3317
Purity: 95%
MF: C12H17ClN2O2
MW: 256.733
Storage: 2-8 degree Celsius
SMILES: Cl.COC1=C(C=CC=C1)C(=O)N1CCNCC1
Catalog No.: GS3317
Purity: 95%
MF: C12H17ClN2O2
MW: 256.733
Storage: 2-8 degree Celsius
SMILES: Cl.COC1=C(C=CC=C1)C(=O)N1CCNCC1
CAS NO.: 100939-98-8;(2-methoxyphenyl)(piperazin-1-yl)methanone hydrochloride. PROPERTIES: This methoxyphenyl piperazine derivative salt appears as a white hygroscopic powder with a molecular weight of approximately 285.8 g/mol (free base). The (2-methoxyphenyl)(piperazin-1-yl)methanone hydrochloride combines a methoxyphenyl group with a piperazine ring and a ketone functionality. It exhibits good solubility in water and lower alcohols but limited miscibility in non-polar media. Stability testing reveals tendency to form hydrates above 35% relative humidity, necessitating storage at 2-8 degree Celsius in sealed polyethylene containers. Handlers should employ deliquescence-resistant tools and maintain environmental humidity below 30%. Skin contact may cause chemical burns in presence of moisture. Inhalation may induce bronchial hyperreactivity; treatment includes anticholinergic inhalers. Eye exposure requires extended rinsing and possible corticosteroid application. Waste should be neutralized with sodium bicarbonate prior to disposal. APPLICATIONS: The (2-methoxyphenyl)(piperazin-1-yl)methanone hydrochloride serves as a key intermediate in the synthesis of various pharmaceuticals. Its methoxyphenyl group provides enhanced solubility in lipid phases compared to non-methoxy analogs. Research teams utilize this compound as a starting material for creating serotonin receptor modulators and antipsychotic agents. The ketone group undergoes reduction to form secondary alcohols for further functionalization. Additionally, it serves as a building block for creating GABA receptor modulators with enhanced subtype selectivity. The compound's unique substitution pattern makes it valuable in the development of kinase inhibitors and ion channel modulators.
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