2-bromo-4-methoxypyrimidine
$400.00
CAS No.: 944709-74-4
Catalog No.: 196413
Purity: 95%
MF: C5H5BrN2O
MW: 189.012
Storage: 2-8 degree Celsius
SMILES: BrC1=NC=CC(=N1)OC
Catalog No.: 196413
Purity: 95%
MF: C5H5BrN2O
MW: 189.012
Storage: 2-8 degree Celsius
SMILES: BrC1=NC=CC(=N1)OC
2-bromo-4-methoxypyrimidine; CAS No.: 944709-74-4; 2-bromo-4-methoxypyrimidine. PROPERTIES: This compound presents a 2-bromo-4-methoxypyrimidine structure, combining a bromine atom and a methoxy substituent on the pyrimidine framework. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 198.0 g/mol (C5H4BrN2O). The melting point ranges between 110-115 C, and it exhibits moderate solubility in common organic solvents like DMSO and DMF while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 2-Bromo-4-methoxypyrimidine serves as a specialized intermediate in pharmaceutical research. Its 2-bromo-4-methoxypyrimidine structure enables diverse reactivity patterns, including palladium-catalyzed cross-coupling reactions at the bromine position and nucleophilic substitution at the pyrimidine ring. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The bromine atom provides a handle for introducing aryl, vinyl, or heterocyclic substituents. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies utilize it as a model system in Medicinal Chemistry journals, focusing on optimizing the 2-bromo-4-methoxypyrimidine scaffold for improved biological activity and target engagement.
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