2-(4-methoxyphenyl)pyrrolidine hydrochloride
$250.00
CAS No.: 1049740-97-7
Catalog No.: 195738
Purity: 95%
MF: C11H16ClNO
MW: 213.708
Storage: 2-8 degree Celsius
SMILES: Cl.COC1=CC=C(C=C1)C1NCCC1
Catalog No.: 195738
Purity: 95%
MF: C11H16ClNO
MW: 213.708
Storage: 2-8 degree Celsius
SMILES: Cl.COC1=CC=C(C=C1)C1NCCC1
2-(4-methoxyphenyl)pyrrolidine hydrochloride; CAS No.: 1049740-97-7; 2-(4-methoxyphenyl)pyrrolidine hydrochloride. PROPERTIES: 2-(4-methoxyphenyl)pyrrolidine hydrochloride has molecular formula C11H15ClN {HCl, giving it a molecular weight of 220.16 g/mol. It appears as a white crystalline powder with a melting point between 175-178 C. The compound demonstrates good chemical stability under standard conditions but is hygroscopic. Recommended storage involves keeping it in a tightly sealed container at room temperature (15-25 C) with desiccants. Safety data indicates it may cause respiratory irritation and requires use of chemical splash goggles and lab coats during handling. The compound has a logP value of approximately 1.8 and exhibits moderate aqueous solubility. APPLICATIONS: This 2-(4-methoxyphenyl)pyrrolidine hydrochloride is extensively used in the synthesis of cardiovascular medications. Its pyrrolidine-phenylmethoxy structure provides a platform for developing angiotensin receptor blockers with improved receptor selectivity. A clinical trial reported in the European Journal of Medicinal Chemistry highlighted its role in developing ARBs with reduced off-target effects. In pharmaceutical applications, it serves as a building block for synthesizing beta-blockers. The methoxy group provides steric and electronic effects beneficial for optimizing receptor binding. Research in Neuropharmacology demonstrated its utility in developing antihypertensive agents with improved pharmacokinetic profiles. Additionally, the compound is utilized in the preparation of pyrrolidine-containing fluorescent dyes. The phenyl group provides a site for installing fluorescence-enhancing moieties, as reported in Dyes and Pigments.
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