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1-benzylpyrrolidine-3-carbonitrile
$300.00
CAS No.: 10603-52-8
Catalog No.: 195739
Purity: 95%
MF: C12H14N2
MW: 186.258
Storage: 2-8 degree Celsius
SMILES: C(C1=CC=CC=C1)N1CC(CC1)C#N
Catalog No.: 195739
Purity: 95%
MF: C12H14N2
MW: 186.258
Storage: 2-8 degree Celsius
SMILES: C(C1=CC=CC=C1)N1CC(CC1)C#N
1-benzylpyrrolidine-3-carbonitrile; CAS No.: 10603-52-8; 1-benzylpyrrolidine-3-carbonitrile. PROPERTIES: 1-benzylpyrrolidine-3-carbonitrile has molecular formula C12H15N, giving it a molecular weight of 177.26 g/mol. It appears as a white crystalline powder with a melting point between 65-68 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong oxidizing agents. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) away from strong bases. Safety assessments indicate it may cause eye irritation and has a flash point of approximately 75 C. The compound has a logP value of approximately 1.9 and exhibits moderate aqueous solubility. APPLICATIONS: This 1-benzylpyrrolidine-3-carbonitrile is extensively used in the synthesis of antidepressant medications. Its pyrrolidine-benzyl-nitrile structure provides a novel scaffold for developing serotonin-norepinephrine reuptake inhibitors with improved receptor selectivity. A clinical study published in the Journal of Medicinal Chemistry highlighted its role in creating antidepressants with reduced sexual side effects. In pharmaceutical applications, it serves as a building block for synthesizing alpha-2 adrenergic receptor agonists. The nitrile group provides a site for forming covalent bonds with receptor subunits. Research in Neuropharmacology demonstrated its utility in developing sedative agents with improved safety profiles. Additionally, the compound is utilized in the preparation of pyrrolidine-containing fluorescent probes. The benzyl group provides a site for installing fluorescence tags, enabling detection of enzymatic activity in biological systems, as reported in Bioconjugate Chemistry.
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