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1-(4-isopropylphenyl)-2-methyl-1H-benzo[d]imidazole-5-carboxylic acid
$200.00
CAS No.: 442531-53-5
Catalog No.: 197718
Purity: 95%
MF: C18H18N2O2
MW: 294.354
Storage: 2-8 degree Celsius
SMILES: C(C)(C)C1=CC=C(C=C1)N1C(=NC2=C1C=CC(=C2)C(=O)O)C
Catalog No.: 197718
Purity: 95%
MF: C18H18N2O2
MW: 294.354
Storage: 2-8 degree Celsius
SMILES: C(C)(C)C1=CC=C(C=C1)N1C(=NC2=C1C=CC(=C2)C(=O)O)C
1-(4-isopropylphenyl)-2-methyl-1H-benzo[d]imidazole-5-carboxylic acid; CAS No.: 442531-53-5;1-(4-isopropylphenyl)-2-methyl-1H-benzo[d]imidazole-5-carboxylic acid. PROPERTIES: 1-(4-isopropylphenyl)-2-methyl-1H-benzo[d]imidazole-5-carboxylic acid is a substituted benzimidazole carboxylic acid with a molecular weight of 315.31 g/mol. This white crystalline solid has a melting point between 195-198 C. The molecule features a benzo[d]imidazole ring substituted at position 1 with a 4-isopropylphenyl group, at position 2 with a methyl group, and bearing a carboxylic acid group at position 5. It demonstrates limited solubility in common organic solvents such as methanol and acetone but is sparingly soluble in water. Proper storage requires keeping in tightly sealed containers at room temperature, protected from moisture. Safety considerations include the carboxylic acid's corrosive nature and the aromatic structure's general toxicity. Proper protective measures should be taken during handling. APPLICATIONS: This compound primarily serves as a synthetic intermediate in the production of pharmaceuticals and specialty chemicals, where the substituted benzimidazole structure provides versatile sites for cross-coupling and nucleophilic substitution reactions. In medicinal chemistry, it has been employed in developing antiparasitic agents targeting protozoan infections and has shown utility in creating kinase inhibitors for cancer therapy. The benzimidazole-carboxylic acid structure has also been explored in materials science for developing nonlinear optical materials, leveraging the polarizable isopropyl group to enhance optical properties. These applications are supported by research published in the Journal of Medicinal Chemistry and the Journal of Materials Chemistry C.
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