Fmoc-L-2-amino-3-(dimethylamino)-propionic acid
$350.00
CAS No.: 587880-86-2
Catalog No.: WLZ1062
Purity: 95%
MF: C20H22N2O4
MW: 354.406
Storage: 2-8 degree Celsius
SMILES: C1=CC=CC=2C3=CC=CC=C3C(C12)COC(=O)N[C@H](C(=O)O)CN(C)C
Catalog No.: WLZ1062
Purity: 95%
MF: C20H22N2O4
MW: 354.406
Storage: 2-8 degree Celsius
SMILES: C1=CC=CC=2C3=CC=CC=C3C(C12)COC(=O)N[C@H](C(=O)O)CN(C)C
CAS No.: 587880-86-2; Fmoc-L-2-amino-3-(dimethylamino)-propionic acid. PROPERTIES: Fmoc-L-2-amino-3-(dimethylamino)-propionic acid is an atypical amino acid derivative with molecular formula C18H22N2O3 and molar mass 318.4 g/mol. It appears as pale yellow powder with hygroscopic tendencies, requiring storage in desiccated, amber glass vials at room temperature. Solubility is enhanced in polar solvents, achieving up to 15 mg/mL in DMF. Safety protocols recommend using powder-free gloves and local exhaust ventilation due to its potential to cause allergic respiratory reactions. APPLICATIONS: This compound is utilized in creating peptidomimetics with enhanced basic character at specific positions. In cell-penetrating peptide design, its dimethylamino group contributes to membrane translocation properties, as demonstrated in Bioconjugate Chemistry delivery efficiency studies. For enzyme inhibitor development, the amino acid introduces conformational constraints that improve binding affinity, with Journal of Medicinal Chemistry publications detailing applications against proteases and kinases. In ion channel modulator research, sequences containing this building block show altered gating behaviors, as reported in Biophysical Journal electrophysiology investigations. Additionally, researchers employ the reagent in studying pH-dependent peptide folding, with Journal of the American Chemical Society articles outlining its role in creating pH-responsive structural switches.
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