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tert-butyl but-3-ynylcarbamate; CAS No.: 149990-27-2; tert-butyl but-3-ynylcarbamate. PROPERTIES: This compound is a tert-butyl but-3-ynylcarbamate appearing as colorless solid. Its molecular weight is approximately 190.25 g/mol. It has melting point around 45-50 C. The compound is moderately soluble in polar aprotic solvents like dimethylformamide. It's moisture sensitive and may hydrolyze upon exposure to atmospheric moisture. Store in tightly sealed containers under nitrogen atmosphere. Keep below 20 C and protect from moisture. Handle with care using appropriate protective equipment when handling powder. APPLICATIONS: tert-butyl but-3-ynylcarbamate is used in organic synthesis as protected amine containing alkyne as described in Organic Letters. It's employed in preparation of certain HIV entry inhibitors mentioned in Journal of Medicinal Chemistry. Additionally, this compound serves as building block for synthesizing carbamate-based agrochemicals reported in Pest Management Science. The terminal alkyne group provides opportunity for Sonogashira coupling reactions in medicinal chemistry applications.